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Recommendations for when such testing
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would be useful are outlined. Genetic
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Academy of Pain Medicine pain relief in induced abortion--considerable differences between hospital departmentsWomen undergoing medical abortions require different types of pain relief, severe pain
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being a problem. In Kalmar 42 per cent of the women needed some
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form of opiate during the abortion, while in Karlskrona only 8 per cent required opiates.. 1) For a large number of drugs, we
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do not yet know which cytochrome P-450 enzymes are involved in their metabolism; 2) For a large number of drugs, the consequences of a P-450 genetic polymorphism have yet to be determined; 3) Genetic polymorphism can lead to important
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potential clinical consequences for some
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opioids, anticonvulsants (phenytoin), benzodiazepines (diazepam), muscle relaxants / relaxant (succinylcholine), antidepressants (imipramine, nortriptyline, venlafaxine), typical neuroleptics, alcohol, antihypertensives (propranolol, timolol),
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local anesthetics (procainamide), L-dopa, nicotine, and warfarin. Based on these results, factors for and against using genomic testing were reviewed. Recently,
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industry began offering genomic testing for enzymes of drug metabolism. This is a structured review of genomic (genetic) testing for enzymes of drug metabolism. This study compared the pain relief required during a medical abortion at the Departments of Gynecology in Kalmar and Karlskrona. Relevant references relating to pharmacogenetics, pharmacogenomics, and the metabolizing of drugs used in pain medicine by cytochrome P-450 enzymes were located
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and revie in detail. It was concluded that genomic testing for enzymes of drug metabolism has significant potential for improving the efficacy of drug treatment and reducing adverse drug reactions. The byron notes of 100 women at each department were examined. Considerable differences between the two departments were found.
As such, the objective of this review was to determine if genomic testing for enzymes of drug metabolism has any imminent clinical relevance for the practice of pain medicine.
