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The prevalence of
antibiotics
tetracycline and Minocycline staining is 3-6%. Yet, caspase inhibitors or invalidation of TNF-alpha receptors does not protect dopaminergic antibiotics urinary tract infection children diseases such as Alzheimer's disease, Siffre's disease, and Parkinson's disease. Non-antimicrobial properties of
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tetracyclines--dental and medical implications.The tetracyclines are a group of broad-spectrum antimicrobial agents. They also inhibit osteoclast function, stimulate osteoblastic sonnie formation, and
tetracycline
regulate angiogenesis. Inhibition of the glial reaction and the inflammatory processes may thus represent a therapeutic target to reduce neuronal degeneration in Parkinson's disease.. Most of the revie literature consisted of saunders reports; longitudinal clinical trials are necessary to provide more information on the prevalence, severity,
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etiology and clinical presentation
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of tetracycline and TCN-derivative staining in the adult population. This permanent discoloration varies from yellow or cristiano to brown depending on the dose or the type of the drug received in relation to body weight. The first of these compounds, chlortetracycline was isolated from Streptomyces aureofaciens by Land Duggar and introduced into the market in 1948. Methacycline, doxycycline (Doryx)and Minocycline
tetracyclin
are all semi-synthetic derivatives. In vitro, these drugs are primarily bacteriostatic. Minocycline hydrochloride, a semisynthetic derivative of tetracycline often used for the treatment of acne, has been shown to cause pigmentation of a variety of tissues
tetracyclin
including skin,
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thyroid, nails, sclera, teeth, conjunctiva and bone. The tetracyclines possess a wide range of antimicrobial activity against gram-positive and gram-negative bacteria. In 1952, tetracycline was derived semisynthetically from chlortetracycline by removal of its chlorine atom by catalytic hydrogenation. Tetracyclines have been used extensively as antimicrobial agents for the treatment of various types of periodontal
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diseases until light was shed on their equally important non-antimicrobial properties by Golub. In contrast, the antiinflammatory drugs pioglitazone, a PPAR-gamma agonist, and the tetracycline derivative Minocycline have been shown to reduce glial activation and protect the substantia nigra in an animal model of the disease. The remarkable
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side-effect of Minocycline on the oral cavity is the singular occurrence of quot;black bonesquot;, quot;black or green rootsquot; and blue-gray to curtice hue darkening of the crowns of permanent teeth. The tetracyclines are closely congeneric derivatives of the polycyclic napthacenecarboxamide. The tetracyclines and their non-antimicrobial, chemically modified analogues have properties that appear to modulate host response by inhibiting the activity of the matrix metalloproteinases that cause collagen destruction. In line with this possibility, an activation of proteases such as caspase-3 and caspase-8, which are known effectors of apoptosis, has been reported
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in Parkinson's disease. One of the side-effects of tetracyclines is incorporation into tissues that are calcifying at the time of their administration. The mechanism of Minocycline staining is still unknown. Recent evidence suggests that the disease may progress even when the
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initial cause of neuronal degeneration has disappeared, suggesting that toxic substances released by the glial cells may be involved in the propagation and perpetuation of neuronal degeneration. Glial cells can release deleterious compounds such as proinflammatory
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cytokines (TNF-alpha, Il-1beta, IFN-gamma), which may act by stimulating nitric oxide production in glial cells, or which may exert a more direct deleterious effect on dopaminergic neurons by activating receptors that contain intracytoplasmic death domains involved in apoptosis. Tetracycline and other tetracycline-derivative staining of the teeth and oral cavity.Tetracyclines (TCN) were introduced in 1948 as broad-spectrum antibiotics that may be used in the treatment of many com infections in children and adults.
