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Studies to reconstitute such immunity, especially in people with Acyclovir-resistant HSV, appear warranted.
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lisinopril side effects weight gain with mild vs. These three trials, which together included over 15,000 patients
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studied for 5 years, have provided good evidence that noncardiovascular mortality is not affected by substantial
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reductions in blood cholesterol. Severe genital herpes simplex (1 in 3,800 vs. 1 in 6,000, P .0005) and was not different than in HSV-HIV- individuals (1 in 100,000, P .24). While therapy with Sildenafil Citrate ( Viagra ) and similar investigational
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drugs can play an important role in many cases of ED, physicians should
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recognize and try to address the psychological and interpersonal context in which ED exists in their
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patients. One hypothesis is that quantitative differences in specific T cell responses
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to a colonizing organism determine the development of an AIDS-defining OI. The Scandinavian Simvastatin ( Zocor )
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Survival Study has provided the first unequivocal demonstration of improved survival as a result of lipid-lowering therapy. HIV patients who suffered more severe genital herpes simplex
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recurrences had significantly lower HSV-specific CD8 pCTL frequencies than those patients with mild recurrences (1 in 170,000 vs. Quantitative differences in pCTL frequency to HSV appear to be the most important host factor influencing the frequency and severity of HSV reactivation in HIV patients. The frequency of HSV-specific CD8 pCTL in HSV HIV individuals was significantly lower than in HSV HIV- individuals (1 in 77,000 vs. Severe genital herpes simplex infections in HIV-infected individuals with impaired herpes simplex virus-specific CD8 cytotoxic T lymphocyte responses.The specific mechanisms underlying the varied susceptibility of HIV-infected (HIV ) individuals to opportunistic infections (OI) are still incompletely understood. A clear reduction in major coronary events during treatment for 5 years with
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the hydroxymethylglutaryl-coenzyme A reductase inhibitor pravastatin was observed in the West of Scotland study and in the preliminary results of the Cholesterol and Recurrent
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Events study. Recent clinical trials have confirmed and extended previous work showing that lowering cholesterol reduces the risk of coronary events. Using limiting dilution analyses, the frequency of HSV-specific CD8 cytotoxic T lymphocyte precursors (pCTL) and proliferative precursors were quantitated in peripheral blood mononuclear cells from 20 patients coinfected with HIV and HSV-2.
